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SUMMARY:‘New protagonists of the tumour microenvironment’ - Dr Ilaria 
 Malanchi\, Tumour-Host Interaction Lab\,Francis Crick Institute\, London 
DTSTART:20190507T103000Z
DTEND:20190507T113000Z
UID:TALK123763@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:*Abstract:*\nThe tumour microenvironment or niche is the vital
  non-cancerous compartment of the tumour structure. Tumour cells and their
  microenvironment establish a synergistic cooperation that characterizes a
 ll aspects of tumour growth\, from onset to metastasis. Importantly\, this
  ever-changing interaction is a key source of cancer cells’ plasticity a
 nd plays an important role in every aspect of tumour progression. Indeed\,
  cancer cells with higher ability to establish favourable crosstalk with t
 heir surrounding are more tumorigenic (1). Thus\, targeting non-tumour-der
 ived cellular components represents a promising avenue to better therapeut
 ic interventions. For instance\, we identify neutrophils as the main compo
 nent and driver of metastatic establishment within the pre-metastatic lung
  microenvironment in mouse breast cancer models. Importantly\, we find tha
 t neutrophil-derived leukotrienes aid the colonization of distant tissue b
 y selectively expanding the sub-pool of cancer cells that retain high tumo
 rigenic potential. Pharmacologic inhibition of the leukotriene-generating 
 enzyme arachidonate 5-lipoxygenase (Alox5) reduces metastasis\, revealing 
 the efficacy of using targeted therapy against a specific tumour microenvi
 ronment component (2). \nUsing an in vivo labelling system\, we now descri
 be the cellular protagonists of the metastatic tissue response to cancer c
 ells. \n\nReferences\n\n1.     del Pozo Martin Y\, Park D\, Ramachandran A
 \, Ombrato L\, Calvo F\, Chakravarty P\, et al. CellReports. 2015 Dec 1\;2
 2(13 (11)):2456–69. \n\n2.     Wculek SK\, Malanchi I. Nature. 2015 Dec 
 9\;17(528):413–7. \n
LOCATION:Sackler Lecture Theatre (Level 7)\, Cambridge Institute for Medic
 al Research
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