BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Computational Neuroscience Journal Club - Xizi Li (CBL)
DTSTART:20190514T150000Z
DTEND:20190514T160000Z
UID:TALK125059@talks.cam.ac.uk
CONTACT:Rodrigo Echeveste
DESCRIPTION:Xizi Li will present:\n\n• Precise Synaptic Balance in the Z
 ebrafish Homolog of Olfactory Cortex\n\n• Peter Rupprecht\, Rainer W. Fr
 iedrich\n\n• Neuron (2018)\n\n• https://www.sciencedirect.com/science/
 article/pii/S0896627318307864\n\n\nAbstract: Neuronal computations critica
 lly depend on the connectivity rules that govern the convergence of excita
 tory and inhibitory synaptic signals onto individual neurons. To examine t
 he functional synaptic organization of a distributed memory network\, we p
 erformed voltage clamp recordings in telencephalic area Dp of adult zebraf
 ish\, the homolog of olfactory cortex. In neurons of posterior Dp\, odor s
 timulation evoked large\, recurrent excitatory and inhibitory inputs that 
 established a transient state of high conductance and synaptic balance. Ex
 citation and inhibition in individual neurons were co-tuned to different o
 dors and correlated on slow and fast timescales. This precise synaptic bal
 ance implies specific connectivity among Dp neurons\, despite the absence 
 of an obvious topography. Precise synaptic balance stabilizes activity pat
 terns in different directions of coding space and in time while preserving
  high bandwidth. The coordinated connectivity of excitatory and inhibitory
  subnetworks in Dp therefore supports fast recurrent memory operations.
LOCATION:Cambridge University Engineering Department\, CBL\, BE4-38 (http:
 //learning.eng.cam.ac.uk/Public/Directions)
END:VEVENT
END:VCALENDAR