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SUMMARY:Three case studies for coexisting mechanisms in protein-pattern fo
 rming systems - Fridtjof Brauns\, LMU Munich
DTSTART:20190904T093000Z
DTEND:20190904T103000Z
UID:TALK129487@talks.cam.ac.uk
CONTACT:Microsoft Research Cambridge Talks Admins
DESCRIPTION:Experimental studies of protein-pattern formation (both in viv
 o and in vitro) have stimulated new interest in the dynamics of reaction
 –diffusion systems. Much of the past theoretical work on pattern formati
 on has focused on idealized two-component models in one spatial dimension.
  In contrast\, biological systems comprise many different components with 
 complex kinetic interactions that play out in three-dimensional geometries
 . I will present three case studies—each combining experiments and theor
 y—which demonstrate that biological systems generically exhibit several 
 distinct and coexisting pattern-forming mechanisms. The theoretical analys
 is is based on local equilibria theory which describes the dynamics of mas
 s-conserving reaction–diffusion systems terms of mass-redistribution and
  moving local equilibria. Based on this physical foundation\, I will show 
 how coexisting mechanisms can emerge from (i) different interaction domain
 s on a single protein species (MinDE system of E. coli)\, (ii) different s
 ubmodules within a network of many protein species (Cdc42 system of buddin
 g yeast)\, and (iii) due to different bulk-volume to surface-area ratios (
 MinDE system of E. coli). This third study highlights the essential role o
 f spatial geometry for systems with bulk-surface coupling.
LOCATION:Auditorium\, Microsoft Research Ltd\, 21 Station Road\, Cambridge
 \, CB1 2FB
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