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SUMMARY:How epithelial cells polarise and why this goes wrong in cancer - 
 Professor Daniel St Johnston\, The Gurdon Institute\, University of Cambri
 dge
DTSTART:20200123T140000Z
DTEND:20200123T150000Z
UID:TALK129502@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Most of our tissue and organs are composed of cells that adher
 e to each other to form epithelial sheets and tubes that act as a barriers
  between our insides and the outside world. In order to form these sheets\
 , all of the cells must first polarise in the same direction\, with their 
 apical surfaces facing outside and their lateral sides forming specialised
  junctions. More than 80% of tumours arise from epithelial tissues and one
  of their hallmarks is that the tumour cells lose their apical-basal polar
 ity. Work over the past 20 years has defined a conserved set of polarity f
 actors that define the apical and basolateral domains of epithelial cells\
 , but how these are related to cancer formation is currently unknown.  I w
 ill discuss the canonical model of epithelial polarity and describe a new 
 component of this system that may explain  how polarity is disrupted in so
 me cancers. I will then discuss evidence that  suggests that one reason wh
 y progress has been slow is because different epithelia polarise by distin
 ct mechanisms.  
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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