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SUMMARY: ‘Activation of transcription factor Nrf2 as a strategy to resto
 re the cellular redox and protein homeostasis’ - Professor Albena Dinkov
 a-Kostova\,Jacqui Wood Cancer Centre\, Division of Cellular Medicine\, Uni
 versity of Dundee  
DTSTART:20191001T103000Z
DTEND:20191001T113000Z
UID:TALK130477@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:Disrupted redox and protein homeostasis and chronic inflammati
 on are characteristic features of most human pathologies. The transcriptio
 n factor Nrf2 regulates the expression of large networks of genes encoding
  proteins that provide powerful and long-lasting protection against damage
  by oxidants and pro-inflammatory agents. Most pharmacological activators 
 of Nrf2 (termed inducers) are electrophiles that target discreet highly re
 active sensor cysteines within Kelch-like ECH-associated protein 1 (Keap1)
 \, the main negative regulator of Nrf2\, impairing the repressor function 
 of Keap1\, and allowing for Nrf2 accumulation and enhanced transcription o
 f its target genes. The Nrf2 regulatory network includes drug metabolizing
 \, antioxidant\, anti-inflammatory and metabolic enzymes\, proteasomal sub
 units and autophagy-related proteins\, and thus Nrf2 has a critical role i
 n the maintenance of the cellular redox and protein homeostasis\, and in t
 he resolution of inflammation. Pharmacological Nrf2 activation with electr
 ophilic inducers\, some of which are in clinical trials\, shows multiple b
 eneficial effects in cell culture and animal models of numerous human path
 ologies\, such as cancer\, epilepsy\, and Huntington’s disease.
LOCATION:Sackler Lecture Theatre (Level 7)\, Cambridge Institute for Medic
 al Research
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