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SUMMARY:Emergence of life-like properties in coacervate droplets - Evan Sp
 ruijt\, Radboud University\, the Netherlands
DTSTART:20191120T103000Z
DTEND:20191120T113000Z
UID:TALK134995@talks.cam.ac.uk
CONTACT:Magdalena
DESCRIPTION:Being able to organize the complex biomolecular chemistry that
  takes place in cells in space and time is essential for life. Liquid-liqu
 id phase separation has emerged as an important biological organizing prin
 ciple that can result in the formation of dynamic membraneless compartment
 s\, also known as coacervate droplets. By studying model coacervate drople
 ts in vitro\, we are able to probe how their unique chemical microenvironm
 ent can affect reactivity\, self-assembly\, phase behaviour and potentiall
 y aggregation of biomolecules. Here\, we focus on how mixtures of coacerva
 tes will typically lead to hierarchically organized multiphase compartment
 s\, and how the enhanced assembly of proteins such FtsZ into filaments ins
 ide these compartments gives rise to spontaneous elongation and splitting 
 upon supply of energy. These insights are not only relevant to better unde
 rstand living cells in health and disease\, but also to guide efforts to b
 uild a functional synthetic cell.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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