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SUMMARY:Bringing electrostatics to light: Electrometry probes a new dimens
 ion at  the molecular scale - Madhavi Krishnan\, Oxford
DTSTART:20200211T130000Z
DTEND:20200211T140000Z
UID:TALK136186@talks.cam.ac.uk
CONTACT:Professor Mike Cates
DESCRIPTION:The desire to “freely suspend the constituents of matter” 
 in order to \nstudy their behavior can be traced back over 200 years to th
 e diaries of \nLichtenberg. From radio-frequency ion traps to optical twee
 zing of \ncolloidal particles\, existing methods to trap matter in free sp
 ace or \nsolution rely on the use of external fields that often strongly p
 erturb \nthe integrity of a macromolecule in solution. We recently introdu
 ced the \n‘electrostatic fluidic trap’\, an approach that exploits equ
 ilibrium \nthermodynamics to realise stable\, non-destructive confinement 
 of a \nsingle macromolecule in a room temperature fluids\, and represents 
 a \nparadigm shift in a nearly century-old field. The spatio-temporal \ndy
 namics of a single electrostatically trapped object reveals \nfundamental 
 information on its properties\, e.g.\, size and electrical \ncharge. We ha
 ve demonstrated the ability to measure the electrical \ncharge of a single
  macromolecule in solution with a precision much \nbetter than a single el
 ementary charge. Since the electrical charge of a \nmacromolecule in solut
 ion is in turn a strong function of its 3D \nconformation\, our approach e
 nables for the first time precise\, general \nmeasurements of the relation
 ship between 3D structure and electrical \ncharge of a single macromolecul
 e\, in real time. I will present our most \nrecent advances in this emergi
 ng area of molecular measurement and \ndemonstrate how such high-precision
  interaction energy measurements may \nbe opening up a unique view of mole
 cular-scale matter in solution.\n\n
LOCATION:MR11\, CMS
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