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SUMMARY:Lister Prize winning Lecture - Remodelling the lung to host unconv
 entional germinal centres - Dr Michelle Linterman\, Group Leader - Lymphoc
 tye Signalling\, Babraham Institute
DTSTART:20200325T120000Z
DTEND:20200325T130000Z
UID:TALK139111@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:The formation of ectopic germinal centres structures in non-ly
 mphoid tissues occurs in many inflammatory conditions including infection\
 , allergy\, autoimmune disease and cancer. Ectopic germinal centres are ag
 gregates of lymphocytes\, myeloid cells and stromal cells that form de nov
 o in response to chronic inflammation and are thought to functionally rese
 mble the immune responses that occur in secondary lymphoid organs. However
 \, we know very little about how these unconventional structures form and 
 almost nothing about their function. Our work has uncovered a novel pathwa
 y that induces ectopic germinal centres structures in the lung after viral
  infection\, highlighting how inflammation can remodel non-lymphoid tissue
 s to support a functional germinal centre.\n\nIntroduction - Dr Martin Tur
 ner\n\nAward presentation - Prof Sir Alex Markham
LOCATION:Babraham - The Cambridge Building - The Petersfield Lecture Theat
 re
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