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SUMMARY:Bringing Rcd4 into the limelight - A forgotten member of the Droso
 phila centriolar inventory  - Pallavi Panda\, Department of Genetics
DTSTART:20200226T173000Z
DTEND:20200226T193000Z
UID:TALK139816@talks.cam.ac.uk
CONTACT:Alexis
DESCRIPTION:Proteins involved in centriole duplication appear to exist and
  function in sub-complexes\; Sas6 binds to phosphorylated Ana2 to initiate
  pro-centriole formation\; Sas4 interacts with centriolar microtubules\; t
 he Cep135:Ana1:Asl network promotes centriole to centrosome conversion ena
 bling recruitment of Plk4 and peri-centriolar material. Here\, we investig
 ate Rcd4\, a previously uncharacterised Drosophila centriolar protein and 
 show that rcd4 mutants exhibit fewer centrioles in many tissues\, aberrant
  mitoses in embryos\, and reduced basal bodies in sensory organs leading t
 o uncoordination. Importantly\, we demonstrate that Rcd4 interacts with An
 a3 to form yet another sub-complex involved in centriole biogenesis. Neith
 er of the proteins participate directly in the mitotic conversion of centr
 ioles to centrosome\, but both are required to load Ana1\, which is essent
 ial for such conversion.  
LOCATION:Gurdon Institute Tea Room
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