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SUMMARY:Study virus assembly and host interactions in vitro and in cells b
 y cryoEM and cryoET  - Peijun Zhang\, Professor of Structural Biology and 
 Wellcome Trust Investigator\, University of Oxford 
DTSTART:20200908T100000Z
DTEND:20200908T110000Z
UID:TALK150253@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:With cryoEM\, structures of purified proteins and protein comp
 lexes can be routinely determined to near-atomic resolution using single p
 article analysis (SPA) method. Structures of macromolecular complexes that
  are intrinsically flexible and non-homogeneous\, and often function in hi
 gher-order assemblies that are difficult to purify\, have recently been an
 alyzed to near near-atomic resolution using cryo-electron tomography and s
 ub-tomogram averaging (cryoET STA). The study of these complexes and assem
 blies in cells using cryoET STA\, coupled with cryoFIB and correlative ima
 ging\, opens a new frontier in structural cell biology. I will present our
  recent studies on HIV-1 capsid and its interaction with host factor cyclo
 philin A\, cellular assembly of human reovirus and infection of SARS-Cov-2
 \, to illustrate the power of integrated multiscale imaging from atoms to 
 cells by cryo-electron microscopy. 
LOCATION:Webinar via Zoom - https://zoom.us/j/97493748184?pwd=Z1dZM2pxUk16
 QytPeU5NVWZ3bnZmdz09 Meeting ID: 974 9374 8184 Passcode: 404662
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