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SUMMARY:Quantifying neuronal loss in frontotemporal dementia – studying 
 the human brain at post mortem - Dr Sanne Kaalund
DTSTART:20210211T131000Z
DTEND:20210211T140000Z
UID:TALK157108@talks.cam.ac.uk
CONTACT:Janet Gibson
DESCRIPTION:Frontotemporal dementia (FTD) is a severe and incurable neurod
 egenerative disease associated with loss of neurons in frontal and tempora
 l cortices\, and abnormal deposition of misfolded and aggregated proteins.
  Although the molecular mechanisms underlying FTD are heterogeneous\, the 
 illness is striking in the specificity of neurodegeneration to layer II an
 d V of the cortex. This creates the opportunity to study how protein inclu
 sions perturb neuronal networks\, and how the pathological specificity at 
 post mortem microscopy may improve ante mortem brain imaging for early dia
 gnosis and tracking of disease progression. Using a set of mathematical an
 d statistically methods\, called stereology\, I am measuring the burden of
  protein pathology and numbers of brain cells in FTD.
LOCATION:ONLINE - Email organiser to request link - Details to be sent by 
 email
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