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SUMMARY:Morphogenesis of the mouse and human embryo beyond implantation - 
 Matteo Molè
DTSTART:20210524T133000Z
DTEND:20210524T143000Z
UID:TALK159094@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:During the transition from pre-implantation to early post-impl
 antation the mammalian embryo undergoes major morphogenetic changes\, lead
 ing to transformation of the blastocyst into the egg-cylinder or bilaminar
  disk configuration\, in mouse or human respectively. We found that integr
 in 1 is required during this transition\, coordinating morphogenesis an
 d promoting survival of the embryo proper. By single cell RNAseq\, we also
  characterised a sequence of events underlying post-implantation developme
 nt of the human embryo. We identified a group of cells which may act as an
  evolutionary-conserved anteriorising signalling centre for the establishm
 ent of the anterior-posterior axis prior to gastrulation. 
LOCATION:Online
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