BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Predicting and understanding the stability of G-Quadruplexes - Oli
 ver Stegle
DTSTART:20090202T110000Z
DTEND:20090202T120000Z
UID:TALK16648@talks.cam.ac.uk
CONTACT:Oliver Stegle
DESCRIPTION:G-quadruplexes are stable four-stranded guanine-rich structure
 s which can form\nfrom DNA and RNA.\nThey are an important component of hu
 man telomeres and play a role in the\nregulation of transcription and tran
 slation.\nThe biological significance of a G-quadruplex is crucially linke
 d with their\nthermodynamic stability. \nHence the prediction of G-quadrup
 lex stability is of vital interest.\nWe present a novel Bayesian predictio
 n framework based\non Gaussian process regression to determine the thermod
 ynamic stability of\npreviously unmeasured G-quadruplex forming sequences 
 \nfrom the sequence information alone. \nWe benchmark our approach on a la
 rge G-quadruplex dataset and compare our\nmethod to standard approaches. \
 nFurthermore we propose an active learning procedure which can be used\nto
  iteratively acquire data in an optimal fashion.\nLastly\, we demonstrate 
 the utility of our procedure on a genome-wide study of\nquadruplexes in th
 e human genome.\n
LOCATION:TCM Seminar Room\, Cavendish Laboratory\, Department of Physics
END:VEVENT
END:VCALENDAR