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SUMMARY:Multi-modal neuroimaging biomarkers in dementia with Lewy bodies: 
 An overview - Dr Elijah Mak\, University of Cambridge
DTSTART:20220609T113000Z
DTEND:20220609T123000Z
UID:TALK171104@talks.cam.ac.uk
CONTACT:87079
DESCRIPTION:*Abstract:* Dementia with Lewy bodies (DLB) is the second lead
 ing cause of degenerative dementia after Alzheimer’s disease (AD)\, acco
 unting for over 100\,000 cases in the UK. While the cardinal features of D
 LB include cognitive fluctuations\, spontaneous parkinsonism and REM sleep
  behavioural disorder and recurrent visual hallucinations\, many people wi
 th DLB also have varying degrees of Alzheimer’s disease pathologies\, su
 ch as amyloid plaques and tau neurofibrillary tangles. Despite its prevale
 nce\, the diagnosis of DLB and consequently its treatment may be complicat
 ed due to the overlapping clinical symptoms between DLB\, AD\, and Parkins
 on’s disease with dementia. To this end\, recent advances in neuroimagin
 g could aid differential diagnosis and help delineate the underlying patho
 logical mechanisms\, and stratification of DLB patients on the basis of AD
  comorbidity. I will present an overview of deep-phenotyping multi-modal i
 maging studies in DLB at the Old Age Psychiatry Group\, highlighting some 
 of the key imaging findings: (a) patterns of grey matter atrophy from stru
 ctural MRI\, (b) neuroinflammation from [11C]-PK11195 PET imaging\, (c) am
 yloid and tau deposition from [11C]-PiB and [18F]-AV1451 PET imaging\, (d)
  and cross-modal relationships among biomarkers.\n\n*Biography:* Dr Elijah
  Mak is a Junior Research Fellow\, funded by the Alzheimer’s Society UK
 \, and a former Gates Cambridge scholar. His fellowship aims to determine 
 whether Neurite Orientation Dispersion and Density imaging (NODDI) could d
 etect cortical microstructure changes (i.e. dendritic arborisation) in dem
 entia with Lewy bodies\, and understand their associations with concomitan
 t Alzheimer’s disease pathologies using PET imaging of amyloid and tau. 
 His broader research interests are in the application of multi-modal neuro
 imaging biomarkers to unravel the complex landscape of disease-related cha
 nges in neurodegenerative conditions and preclinical dementia. Before his 
 current position\, he obtained his PhD on neuroimaging in Lewy body diseas
 es at the Department of Psychiatry\, University of Cambridge\, and complet
 ed a post-baccalaureate MRI Fellowship at the University of Buffalo Neuroi
 maging Analysis Centre\, New York\, and the National Neuroscience Institut
 e\, Singapore. For more information on Dr Mak\, please visit: https://www.
 neuroscience.cam.ac.uk/directory/profile.php?fkm24 \n
LOCATION:Zoom (Please contact mho28@medschl.cam.ac.uk)
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