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SUMMARY:Endothelial cell function and placental angiogenesis - Dr Steve Ch
 arnock-Jones\, Dep. of Obstetrics and Gynaecology
DTSTART:20090401T135500Z
DTEND:20090401T142000Z
UID:TALK17129@talks.cam.ac.uk
CONTACT:Gigi Moller
DESCRIPTION:The placenta serves to bring the maternal and fetal circulator
 y systems into close proximity to allow efficient transfer of oxygen\, nut
 rients and waste products.  This requires profound and substantial growth 
 and remodeling of blood vessels.  These processes are sensitive to changes
  in the local placental environment and can be disturbed under pathologica
 l conditions leading to aberrant vessel architecture and compromise of pla
 cental function.  The coordination of appropriate and well-ordered growth 
 depends on the complex integration of numerous contact and soluble factor-
 mediated signals.  Endothelial behavior ultimately depends on the cellular
  genome and this can be interrogated by investigating changes in the trans
 cript profile under differing conditions.  We have sought to define “reg
 ulatory gene networks” in endothelial cells to further our understanding
  endothelial cell and hence\, placental function.  To do this we have anal
 yzed the endothelial transcript profile after knocking down approximately 
 400 different transcripts.  Using Bayesian statistical methods\, we have m
 odeled the transcript regulatory network.  This has shown that there is a 
 relatively small number of “hub-like” genes that play a key role in re
 gulating endothelial cell fate.  The array data is a substantial resource 
 that will be useful in unraveling endothelial behavior under a range of di
 ffering stimuli.  
LOCATION:Centre for Mathematical Sciences\, Meeting Room 2
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