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SUMMARY:Modelling bet-hedging: A link between cancer and the emergence of 
 multicellularity - Frank Ernesto  Alvarez Borges (Université Paris-Dauphi
 ne)
DTSTART:20220503T135000Z
DTEND:20220503T143500Z
UID:TALK173681@talks.cam.ac.uk
DESCRIPTION:Confronted with the biological problem of managing plasticity 
 in cell populations\, which is in particular responsible for transient and
  reversible drug resistance in cancer\, we propose a rationale consisting 
 of an integro-differential and a reaction-advection-diffusion equation\, t
 he properties of which are studied theoretically and numerically. By using
  a constructive finite volume method\, we show the existence and uniquenes
 s of a weak solution and illustrate by numerical approximations and their 
 simulations the capacity of the model to exhibit divergence of traits. Thi
 s feature may be theoretically interpreted as describing a physiological s
 tep towards multicellularity in animal evolution and\, closer to present-d
 ay clinical challenges in oncology\, as a possible representation of bet h
 edging in cancer cell populations.
LOCATION:Seminar Room 2\, Newton Institute
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