BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Programming phase behavior in multicomponent biopolymer solutions 
 - Prof. William Jacobs\, Princeton
DTSTART:20220606T130000Z
DTEND:20220606T133000Z
UID:TALK175253@talks.cam.ac.uk
CONTACT:Dr Stephen Cox
DESCRIPTION:Intracellular biopolymer solutions\, such as the cytosol and t
 he nucleoplasm\, can demix to form a wide variety of phase-separated conde
 nsates. Since a single intracellular compartment may feature multiple coex
 isting condensates with distinct compositions\, it is natural to ask how r
 eliably such complex phase behavior can be "programmed" into a biopolymer 
 solution containing hundreds of components. Here we describe a theoretical
  model of phase separation in which components may be shared among multipl
 e immiscible condensates. Combining convex optimization techniques and mol
 ecular simulation\, we demonstrate that a surprisingly large number of suc
 h condensates can be programmed by rationally tuning the intermolecular in
 teractions. This approach reveals general rules governing the phase behavi
 or of multicomponent systems and establishes an efficient method for desig
 ning complex mixtures that phase separate into condensates with prescribed
  compositions.\n
LOCATION:Venue to be confirmed
END:VEVENT
END:VCALENDAR