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SUMMARY:Programmable Folding of Droplet Colloidomers - Professor Jasna Bru
 jic\, NYU
DTSTART:20221102T143000Z
DTEND:20221102T153000Z
UID:TALK176888@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:The cutting edge of materials science consists of self-organiz
 ing matter into desired\, reconfigurable shapes to perform wide-ranging fu
 nctions. The past decade has witnessed major innovations in the versatilit
 y of the building blocks\, ranging from DNA and RNA on the nanoscale\, thr
 ough designer colloids\, to handshaking materials on the macroscale. As in
  a jigsaw puzzle\, one can reliably self-assemble structures with an arbit
 rary shape if all the pieces are distinct\, but simpler systems with fewer
  species have so far been limited to the assembly of exotic crystals. Insp
 ired by Nature’s strategy of folding biopolymers into specific protein a
 nd RNA structures\, here we introduce a model system of alternating drople
 t chains (ABAB…) with programmable DNA interactions that fold downhill i
 nto unique geometries\, i.e.\, foldamers\, in 2D. Combining experiments\, 
 simulations and theory\, we show that optimizing the order in which second
 ary interactions are switched on selects a dozen out of 619 folded geometr
 ies with a near-perfect yield in chains up to N=13 droplets. Randomizing d
 roplet sequence and adding a third flavor improves the folding success rat
 e to more than half of all geometries\, outlining the limits of a minimal 
 folding alphabet. These supracolloids can in turn interact to make more co
 mplex architectures\, such as dimers\, tubules and mosaics\, seeding a new
  generation of life-like materials. Our results are independent of dynamic
 s and therefore apply to polymeric materials with hierarchical interaction
 s on all length scales\, from organic molecules all the way to Rubik’s s
 nakes.
LOCATION:Wolfson Lecture Theatre\, Dept of Chemistry and Zoom
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