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SUMMARY:Whodunnit in the genome: Fingerprints of mutagenesis reveal culpri
 ts of cancer - Professor Serena Nik-Zainal from Early Cancer Institute\, U
 niversity of Cambridge
DTSTART:20230427T130000Z
DTEND:20230427T140000Z
UID:TALK177887@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Whole genome sequencing permits exploration of the entirety of
  the cancer genome\, per patient\, revealing all causally-implicated drive
 r mutations and mutational signatures that have arisen through carcinogene
 sis. Mutational signatures are the imprints of DNA damage and DNA repair p
 rocesses that have been operative during tumorigenesis. First derived in b
 reast cancers\, they are biologically informative\, providing clues regard
 ing all the mutagenic processes that have contributed to the developmental
  history of each patient’s cancer. In this lecture\, I shall provide an 
 update on the field\, focusing on validation of these abstract mathematica
 l concepts\, untangling the mechanisms underpinning mutation patterns in h
 uman cancers\, and describing the new insights that we have gained through
  combinations of computational analysis and experiments in cell-based syst
 ems. We showcase how mutational-signature-based clinical algorithms have b
 een developed\, describe the path taken in translating these towards medic
 al utility and for balance\, highlight some of the hurdles that need to be
  navigated in genomic research. 
LOCATION:Biffen Lecture theatre and Zoom
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