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SUMMARY:Population structure and effects of consanguinity on complex disea
 se in British South Asians - Dr Hilary Martin from Wellcome Sanger Institu
 te\, Hinxton\, Cambridge 
DTSTART:20230608T130000Z
DTEND:20230608T140000Z
UID:TALK177890@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Previous genetic and public health research in the Pakistani p
 opulation has focused on the role of consanguinity in increasing recessive
  disease risk\, but little is known about its recent population history\, 
 the effects of endogamy\, or effects of consanguinity on complex disease r
 isk. I will first describe work we have done elucidating fine-scale popula
 tion structure\, history and consanguinity patterns using genotype chip da
 ta from 2\,200 British Pakistanis from the Born in Bradford cohort. I will
  then present recent results demonstrating an effect of consanguinity on r
 isk of several common diseases in three large cohorts (Genes & Health\, co
 mprising 50k British Pakistanis and Bangladeshis\, UK Biobank\, and 23andM
 e)\, including a new approach to deal with confounding.
LOCATION:Biffen Lecture theatre and Zoom
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