BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:Insights into cortical organisation and neurodevelopment from a ge nome wide association study (GWAS) of 2\,347 structural cortical phenotype s - Dr Varun Warrier (University of Cambridge) DTSTART:20221021T153000Z DTEND:20221021T170000Z UID:TALK177977@talks.cam.ac.uk CONTACT:John Mollon DESCRIPTION:Abstract. Our understanding of the genetic architecture of th e development of the human cerebral cortex is limited both in terms of the diversity of brain structural phenotypes and the anatomical granularity o f their associations with genetic variants. Here\, we conducted genome-wid e association meta-analysis of 13 structural and diffusion magnetic resona nce imaging (MRI)-derived cortical phenotypes\, measured globally and at 1 80 bilaterally averaged regions in 36\,843 individuals. These phenotypes i nclude cortical thickness\, surface area\, grey matter volume\, and measur es of folding\, neurite density\, and water diffusion. We identified 4\,35 3 experiment-wide significant loci across all genome-wide association stud ies (GWAS). We demonsted varying levels of pleiotropy among the 13 phenoty pes and across the 180 bilateral cortical regions. Multiple lines of analy ses identified distinct genetic latent structures and causal relationships among the phenotypes\, partly relating to different underlying developme ntal and cellular mechanisms. We also identified\n differential enrichment for human-specific evolutionary signatures\, and neurodevelopmental and c onstrained genes across the 13 phenotypes. Finally\, we identified comple x inter-phenotype and inter-regional genetic relationships among the 13 ph enotypes which reflect developmental differences among these phenotypes. T hese analyses provide unprecedented granular insights into the development \, evolution\, and genetic organisation of the human cortex LOCATION:Ground Floor Lecture Theatre\, Department of Psychology END:VEVENT END:VCALENDAR