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SUMMARY:Cell death as an antimicrobial mechanism against extracellular bac
 terial infection - Assistant Professor Chen Kaiwen\, National University o
 f Singapore. Hosted by Professor Clare Bryant.
DTSTART:20221005T150000Z
DTEND:20221005T160000Z
UID:TALK178541@talks.cam.ac.uk
DESCRIPTION:Programmed necrosis including pyroptosis and necroptosis promo
 te host resistance against infection as it destroys the replicative niche 
 of intracellular pathogens. In contrast\, whether and how necrotic cell de
 ath drives antimicrobial defence against extracellular pathogens is less d
 efined. To address these questions\, we examined innate immune and cell de
 ath signalling upon challenge with two enteric extracellular pathogens: Ye
 rsinia pseudotuberculosis and Citrobacter rodentium. Here\, we demonstrate
  that Y. pseudotuberculosis and C. rodentium triggers apoptotic caspase ac
 tivation\, which cleaves the family of gasdermin proteins to trigger pyrop
 tosis and host defence in vivo. We further show that differential inhibiti
 on of NF-kB signalling by extracellular pathogens dictate whether myeloid 
 cells undergo pyroptosis or necroptosis.
LOCATION:Hybrid meeting\, Jeffrey Cheah Biomedical Centre Lecture Theatre 
 and Via Zoom\, for more details go to https://www.immunology.cam.ac.uk/
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