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SUMMARY:Multi-organ FGF crosstalk orchestrates the construction of the wat
 er conserving cryptonephridial complex in a beetle  - Robin Beaven\, Unive
 rsity of Edinburgh
DTSTART:20221017T133000Z
DTEND:20221017T143000Z
UID:TALK183107@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:Tenebrionid beetles can survive in arid environments\, and a k
 ey feature underlying their ability to conserve water is the cryptonephrid
 ial complex (CNC). It recovers water from the rectal contents and recycles
  it back to the body. The complex arises from a radical reorganisation of 
 the insect body plan. It comprises two organs found in most insects\, the 
 hindgut and renal/Malpighian tubules\, which come to lie in counter curren
 t arrangement. The renal tubules generate a high ionic concentration to dr
 aw water out of the hindgut and return it to the body. It is surrounded by
  an insulating layer of tissue\, the perinephric membrane\, which appears 
 to be unique to insect CNCs. \n\nIn the Denholm lab we are studying how th
 is organ system develops\, including how differentiation of the specialise
 d cells within it is controlled. Here I will talk about the mechanisms by 
 which the distinct tissues generating the CNC are assembled during develop
 ment. Using Tribolium\, we find that sequential crosstalk between the hind
 gut\, renal tubules and perinephric membrane precursor cells\, involving m
 ultiple Fibroblast Growth Factor (FGF) ligands and receptor isoforms\, est
 ablishes the counter current configuration and close apposition of the rec
 tum with renal tubules\, as well as the recruitment of the perinephric mem
 brane. We also identify that the perinephric membrane develops from a dist
 inct population of mesodermal cells not previously described. This provide
 s an elegant example of FGF signalling orchestrating elaborate morphogenic
  interactions between three tissues\, to generate one of the most powerful
  water conservation systems in nature. \n\n 
LOCATION:Online
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