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SUMMARY:Building your life-support system\; a new paradigm for human place
 ntal development - Professor Graham Burton\, Department of Physiology Deve
 lopment & Neuroscience 
DTSTART:20230213T180000Z
DTEND:20230213T190000Z
UID:TALK185810@talks.cam.ac.uk
CONTACT:Beverley Larner
DESCRIPTION:Growth during the intrauterine period is a critical determinan
 t of life-long health. During this period the placenta acts as the baby’
 s life-support system\, transferring nutrients and orchestrating maternal 
 adaptations to the pregnancy. But what stimulates formation of the placent
 a? Development of the human placenta is precocious\, and for many years wa
 s considered the pinnacle of evolutionary advance amongst mammals by provi
 ding early and intimate access to the maternal circulation. Over the last 
 two decades our understanding of the physiology of early pregnancy has und
 ergone radical revision. It is now appreciated that for the first three mo
 nths the placenta is nourished by the secretory lining of the uterus rathe
 r than maternal blood. Furthermore\, evidence from domestic species and re
 cently derived human organoid cultures indicates that a signalling dialogu
 e operates between the placenta and the uterus\, increasing the release of
  growth factors and nutrients by the latter. In this way\, the placenta st
 imulates its own development\, ready to support the baby. Evidence for thi
 s concept will be presented\, and the clinical implications discussed.
LOCATION:Bristol-Myers Squibb Lecture Theatre\, Department of Chemistry
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