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SUMMARY:Investigating drug-induced effects on cardiac electrophysiological
  function: from ion channels to the ECG - Rodriguez\, B (Oxford)
DTSTART:20090722T090000Z
DTEND:20090722T091500Z
UID:TALK19141@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Many drugs fail to reach the market due to adverse side effect
 s on the heart\, and this translates into important socio-economic costs. 
 A major concern for society\, regulatory agencies and industry is that dru
 g-induced alterations in cardiac function can increase the risk of develop
 ment of potentially life threatening arrhythmias\, such as Torsades de Poi
 ntes. Given the limitations of in vitro and in vivo testing in preclinical
  prediction of drug cardiotoxicity\, there is increasing interest in in si
 lico methods to supplement experimental methods. This presentation will de
 scribe how advanced computational techniques are developed and used in our
  group to investigate the mechanisms of drug action on cardiac electrophys
 iological function\, from the ionic to the ECG level. Our main aim is to u
 nravel the mechanisms of drug-induced arrhythmic risk in the context of hi
 gh inter-subject electrophysiological variability\, and to propose novel a
 rrhythmic risk biomarkers based on this research. 
LOCATION:Seminar Room 1\, Newton Institute
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