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SUMMARY:Development of a virtual heart - Part l - Boyett\, M (Manchester)
DTSTART:20090720T133000Z
DTEND:20090720T134500Z
UID:TALK19150@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Development of a virtual heart requires detailed anatomical mo
 dels together with a family of action potential models for the different h
 eart regions. In this and the following presentation\, we will review prog
 ress to develop a virtual rabbit heart at the University of Manchester. Th
 is presentation focuses on the cardiac conduction system\, an essential el
 ement of a virtual heart. Based on serial sectioning\, histology and immun
 olabelling of marker proteins\, we have constructed 3D anatomical models o
 f the rabbit sinoatrial node1 (SAN\; pacemaker of heart) and the rabbit at
 rioventricular node2 (AVN\; responsible for action potential conduction fr
 om atria to ventricles) as mathematical arrays. The model of the SAN inclu
 des both the centre and periphery of the SAN\, whereas the model of the AV
 N includes the transitional zone (fast pathway)\, the inferior nodal exten
 sion (slow pathway) and the penetrating bundle. Most recently\, we have co
 nstructed a 3D anatomical model (mathematical array) of the right atrium o
 f the rabbit heart based on high resolution MRI. The model of the right at
 rium includes 18 segmented objects\, including the SAN and AVN and the maj
 or atrial muscle bundles\, such as the crista terminalis. In 2000 we devel
 oped biophysically-detailed models of the action potentials in the centre 
 and periphery of the rabbit SAN.3 More recently\, we have developed biophy
 sically-detailed models of the AN\, N and NH action potentials (found pred
 ominantly in transitional zone\, inferior nodal extension and penetrating 
 bundle\, respectively) of the rabbit AVN.4 We are using the 3D anatomical 
 models together with the cellular automaton model\, the Fitzhugh-Nagumo eq
 uations or biophysically-detailed action potential models to compute actio
 n potential conduction through the tissue during normal and abnormal activ
 ity (such as AVN reentry). As an alternative strategy\, we are using the b
 iophysically-detailed action potential models together with an idealised 1
 D anatomical model of the AVN to explore the complex electrophysiology of 
 the AVN (such as control of AVN conduction by parasympathetic nervous syst
 em). \n\nReferences (1) H. Dobrzynski et al. Circulation 2005\;111:846-54.
  (2) J. Li et al. Circ Res 2008\;102:975-85. (3) H. Zhang et al. Am J Phys
 iol 2000\;279:H397-H421. (4) S. Inada et al. Biophys J 2009 (under revisio
 n).
LOCATION:Seminar Room 1\, Newton Institute
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