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SUMMARY:Study of blood flow impact on growth of blood clot using a multi-s
 cale model - Alber\, M (North Dame)
DTSTART:20090722T134500Z
DTEND:20090722T140000Z
UID:TALK19165@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:The hemostatic system has evolved to prevent the loss of blood
  at the site of vascular injury. The response is rapid to limit bleeding a
 nd is regulated to prevent excessive clotting that can limit flow. The pro
 cesses that are involved in the assembly of a thrombus (blood clot) includ
 e complex interactions among multiple molecular and cellular components in
  the blood and vessel wall occurring under fluid flow. Formation of a thro
 mbus (thrombogenesis) involves the close interplay between many processes 
 that occur at different scales (subcellular\, cellular and multicellular).
  In the past\, these processes have been studied separately. \n\nIn this t
 alk an extended multi-scale model will be described for studying the forma
 tion of platelet thrombi in blood vessels. The model describes the interpl
 ay between viscous\, incompressible blood plasma\, activated and non-activ
 ated platelets\, as well as other blood cells\, activating chemicals\, fib
 rinogen and vessel walls. The macroscale dynamics of the blood flow is rep
 resented by the continuous submodel in the form of the Navier-Stokes equat
 ions. The microscale cell-cell interactions are described by extended stoc
 hastic lattice and off-lattice models. Simulations indicate that increase 
 in flow rates leads to greater structural heterogeneity of the clot. As he
 terogeneous structural domains within the clot affect thrombus stability\,
  understanding the factors influencing thrombus structure is of significan
 t biomedical importance. \n\nXu\, Z.\, Chen\, N.\, \, Kamocka\, M.M.\, Ros
 en\, E.D.\, and M.S. Alber [2008]\, Multiscale Model of Thrombus Developme
 nt\, Journal of the Royal Society Interface 5 705-722. \n\nXu\, Z.\, Chen\
 , N.\, Shadden\, S.\, Marsden\, J.E.\, Kamocka\, M.M.\, Rosen\, E.D.\, and
  M.S. Alber\, Study of Blood Flow Impact on Growth of Thrombi Using a Mult
 iscale Model\, Soft Matter DOI:10.1039/b300001a (to appear).
LOCATION:Seminar Room 1\, Newton Institute
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