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SUMMARY:"Phospholipase and lysophospholipase D signalling in cancer" - Pro
 f. Michael Wakelam\, Institute Director\, The Babraham Institute
DTSTART:20091020T110000Z
DTEND:20091020T120000Z
UID:TALK19206@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:Lipid signaling pathways regulate a plethora of cell processes
  including proliferation\, growth survival and migration\; they also contr
 ol acute responses such as contraction and metabolism. Significant work ha
 s demonstrated that lipid signaling pathways play a key role in cancer tho
 ugh this has focused primarily upon PI3kinase signaling. We have adopted t
 wo distinct approaches to determining the importance in other lipid signal
 ing pathways in malignancy. Firstly in this presentation the evidence for 
 phospholipase D and lysophospholipase D (autotaxin) in regulating cell gro
 wth and proliferation will be presented emphasizing the roles of the two l
 ipid products phosphatidic acid and lysophosphatidic acid (LPA) and their 
 cross talk with sphingolipid signallinf (ceramide and S1P) in Hodgkin’s 
 lymphoma\, Runx-induced transformation and NPC. Secondly the development o
 f non-biased lipidomic analysis of colorectal cancer by mass spectrometry 
 is pointing to the importance of unsuspected lipid signaling pathways in c
 ancer.
LOCATION:CRI Lecture Theatre
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