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SUMMARY:An Old Story: What happens to tissues when we age - Prof. Melinda 
 Duer
DTSTART:20230313T180000Z
DTEND:20230313T193000Z
UID:TALK197626@talks.cam.ac.uk
CONTACT:Daniel Lim
DESCRIPTION:The extracellular matrix (ECM) forms the bulk of our structura
 l tissues and provides them with their particular mechanical properties. A
 t the microscopic level\, it provides the scaffold which supports cells bu
 t more intriguingly\, at the molecular level\, it provides the communicati
 on system between the cells in the tissue and the signals that drives the 
 individual behaviour of cells. Ultimately\, if we can understand how the e
 xtracellular matrix molecular structure and dynamics dictates the behaviou
 r of cells\, then we can develop ways to combat the effects of ageing\, fo
 r instance\, by doing chemistry in the extracellular matrix to drive the n
 ecessary change in cell behaviour. However\, understanding the molecular l
 evel properties of the extracellular matrix has been hampered by the lack 
 of methods to study tissues at the atomic scale. In this talk\, I will des
 cribe the interdisciplinary approaches my group has taken over the last de
 cade to tackle these complex questions\, including in calcified tissues\, 
 both physiologically calcified bone and pathological vascular calcificatio
 n.
LOCATION:Wolfson Lecture Theatre\,  Department of Chemistry\, Lensfield Ro
 ad
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