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SUMMARY:Connecting spaces and scales in embryos - Jesse Veenvliet 
DTSTART:20230313T143000Z
DTEND:20230313T153000Z
UID:TALK197938@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:Embryonic development requires multi-scale coordination of tis
 sue morphogenesis\, cellular \n behaviours\, and gene expression to ensure
  highly reproducible differentiation outcome at the \n systems level. A de
 ep understanding of the feedbacks that govern such robustness requires the
  study of the processes that pattern and shape the embryo in live specimen
 s\, in toto\, across spatial and temporal scales. In mammalian embryogenes
 is\, this remains a major challenge as the embryo develops in utero\, prec
 luding easy accessibility. These impediments can be overcome by coaxing pl
 uripotent stem cells to form three-dimensional embryonic organoids (or ste
 mbryos) in vitro. Gastruloids are stembryos that break symmetry\, elongate
  and self-organise the major body axes\, but lack the stereotypical archit
 ecture of the embryo. We have shown that the latter can be unlocked by pre
 cisely timed addition of an extracellular matrix\, resulting in trunk-like
 -structures  (TLS) that molecularly and morphologically resemble the core 
 part of the embryonic trunk. In contrast to its in vivo counterpart\, thes
 e stembryos are easy to access\, track\, manipulate and scale. I will expl
 ain how we leverage these unique properties to identify minimal sets of in
 puts necessary to pattern and shape the mammalian embryo through controlle
 d modulations of the system. Moreover\, I will discuss novel frameworks we
  have developed that allow us to connect transcriptional\, cellular and mo
 rpho-states in space and time\, and how these help us to uncover the desig
 n principles of regulative development during critical windows of mammalia
 n embryo morphogenesis. \n\n 
LOCATION:Online
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