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SUMMARY:Lymphoid tales: TNFAIP8 in glucocorticoid killing – E4BP4 and th
 e origin of NK cells - Dr Hugh Brady\, Division of Immunology and Infectio
 n\, Imperial College London
DTSTART:20091012T113000Z
DTEND:20091012T123000Z
UID:TALK20005@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:Glucocorticoids have significant immunoregulatory actions on t
 hymocytes and T-cells and promote cell death by activating an apoptotic pr
 ogramme that requires transcriptional regulation.  Candidate genes to regu
 late glucocorticoid-mediated thymocyte apoptosis were identified by DNA mi
 croarray and and assayed in reconstituted fetal thymic organ culture (FTOC
 ).  Based on this we propose that Tnfaip8 is crucial gene in regulating gl
 ucocorticoid-mediated apoptosis of thymocytes.\n\nNatural Killer (NK) cell
 s are an integral part of innate immunity and also have significant influe
 nce on the regulation of adaptive immunity.  We have identified E4bp4 as a
  gene responsible for specifying NK cell lineage commitment and shown that
  mice lacking E4bp4 have no NK cells.  E4bp4 acts via the Id2 transcriptio
 n factor to control NK cell production.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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