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SUMMARY:The role of frustration in cell-fate network dynamics - Herbert Le
 vine (Northeastern University)
DTSTART:20230706T130000Z
DTEND:20230706T133000Z
UID:TALK201079@talks.cam.ac.uk
DESCRIPTION:Recent research into the analysis of binary networks responsib
 le for cell fate decisions (such as the epithelial-mesenchymal transition 
 of relevance for cancer metastasis) have revealed that these networks exhi
 bit frustration-free states which dominate the basins of attraction. Conse
 quences of this fact for ODE versions of these processes include the colla
 pse of dynamics onto a very small subset of relevant variables and the con
 comitant ability to coarse-grain otherwise unmanageably large systems. &nb
 sp\;This talk will review these findings and also present some new specula
 tions regarding implications of this picture for the response of these sys
 tems to large perturbations\, as might be relevant for a better understand
 ing of the phenomenon of drug persistence.
LOCATION:Seminar Room 1\, Newton Institute
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