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SUMMARY:Inferring intracellular mechanics from active and passive measurem
 ents - Timo Betz (Georg-August-Universität Göttingen)
DTSTART:20230704T150000Z
DTEND:20230704T153000Z
UID:TALK201127@talks.cam.ac.uk
DESCRIPTION:Many biological systems rely on fundamental physical principle
 s for their proper function. A key example are mechanical processes such a
 s force generation and adaptation of stiffness and viscosity that have bee
 n instrumental to explain complex biomedical questions with physical conce
 pts. Such advances in understanding cell biology by physical approaches ha
 ve been largely driven by new methods that allow to quantify biological pr
 ocesses and to construct theoretical models with high predictive power. I 
 will present our recent approaches that allow to study active force genera
 tion and mobility in different cellular systems. Combining optical tweezer
  based cell mechanics measurements with precise particle fluctuation analy
 sis\, we demonstrate a tuning of intracellular mechanics during cell divis
 ion. Using the same tools\, we can furthermore define a mechanical fingerp
 rint that allows to separate different cell types based on their intracell
 ular active mechanics. While these approaches still require a high precisi
 on optical tweezer measurement\, a new approach can yield the same informa
 tion using a simple passive observation. Here we exploit the Onsager princ
 iple to extract the non-equilibrium energy that is injected in the system.
  We derive a new quantity\, the mean back relaxation (MBR) which allow to 
 extract more information from confined trajectories than a classical MSD. 
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LOCATION:Seminar Room 1\, Newton Institute
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