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SUMMARY:Mechanical behaviors of collective cell assemblies during migratio
 n and extrusion. - Benoit Ladoux (Institut Jacques Monod)
DTSTART:20230706T080000Z
DTEND:20230706T090000Z
UID:TALK201148@talks.cam.ac.uk
DESCRIPTION:Epithelia are communities of epithelial cells with close inter
 cellular communications and of highly ordered coordination in their motili
 ty. Tissues can adjust their internal contractile stresses and organizatio
 n in response to different stimuli\, leading to distinct dynamics. Mechani
 cal&nbsp\;properties of epithelial tissues are important for our understan
 ding in many vital biological processes\, including homeostasis\, morphoge
 nesis\, and metastasis and are tightly regulated by cell-cell interactions
 . I will present examples highlighting the importance of collective behavi
 ours to understand tissue regulation. In the first part\, I will focus on 
 collective cell migration and the emergence of cell polarity. In the secon
 d part\, i will talk about cell extrusion form epithelial tissues and how 
 mechanics can regulate the fate of extruding cells. 
LOCATION:Seminar Room 1\, Newton Institute
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