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SUMMARY:LMB Seminar: AlphaFold2 as a Tool for Cell Biology - Ron Vale\, Ex
 ecutive Director\, Janelia Research Campus\, HHMI
DTSTART:20230717T150000Z
DTEND:20230717T160000Z
UID:TALK201367@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:A game-changing computational tool has arrived on scene—Alph
 afold2\, the AI-powered protein structure prediction algorithm developed b
 y DeepMind. I will discuss two examples of how we have used AlphaFold2 to 
 inform our experiments to understand biological motility. The first study 
 combines cryo-EM tomography with Alphafold2 to identify novel proteins in 
 mammalian sperm flagella and then study their function in sperm motility. 
 The second study involves dissecting the regulation of adapter proteins th
 at link dynein and kinesin motors onto mitochondria. These case studies re
 veal how predicted protein structures from AlphaFold2\, while imperfect\, 
 can guide experiments that yield new insight into cell biological processe
 s
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m\, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96873425169?pwd=b0lIVEhaSUVV
 cTNEc21SR21EWjVsUT09
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