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SUMMARY:New Technologies for the Synthesis\, Semi-Synthesis and Biosynthes
 is of Modified Peptides and Proteins - Professor Richard J. Payne\, Univer
 sity of Sydney
DTSTART:20230623T130000Z
DTEND:20230623T140000Z
UID:TALK201373@talks.cam.ac.uk
CONTACT:Echo Wu Williamson
DESCRIPTION:The renaissance in the use of peptides and proteins as therape
 utic agents has led to significant demand for new technologies to rapidly 
 and efficiently access these biomolecules\, especially those bearing tailo
 r-made modifications to maximize specificity and activity\, or to probe bi
 ological function (e.g. through incorporation of post-translational modifi
 cations\, fluorophores and/or imaging reagents).1 We have recently develop
 ed a number of synthetic and semi-synthetic technologies that enable effic
 ient production of peptides and proteins with homogeneous post-translation
 al modifications at pre-determined sites.2\,3 This talk will highlight the
  utility of these technologies for: (1) manufacturing peptidic drugs under
  continuous flow conditions\,3 and (2) generating proteins with site-speci
 fic and homogeneous post-translational modifications.4-6 The talk will con
 clude with our efforts to employ peptide display methods with genetic repr
 ogramming to generate high affinity cyclic peptides for a range of therape
 utic targets.7-9\n\nReferences\n\n1	S. Kulkarni et al. Nature Rev. Chem. 2
 018\, 2\, 0122.\n2	S. Kulkarni et al. Nature Protocols\, 2019\, 14\, 2229.
 \n3	T. Chisholm et al. J. Am. Chem. Soc. 2020\, 142\, 1090\n4	B. Premdjee 
 et al. J. Am. Chem. Soc. 2021\, 143\, 5336\n5	S. Kulkarni et al. Angew. Ch
 em. Int. Ed. 2022\, 61\, e202200163\n6	L. Dowman et al. Nature Commun. 202
 2\, 13\, 6885.\n7	J. Johansen-Leete et al. J. Am. Chem. Soc. 2020\, 142\, 
 9141 \n8	J. Johansen-Leete et al. Chem. Sci. 2022\, 13\, 3826\n9	A. Norman
  et al. ACS Cent. Sci. 2021\, 7\, 1001  
LOCATION:Pfizer  Lecture Theatre\,  Department of Chemistry
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