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SUMMARY:RNA Controls DNA in the Human Cell Nucleus - Tom Cech\, Distinguis
 hed Professor of Biochemistry\, University of Colorado Boulder\, and Inves
 tigator\, Howard Hughes Medical Institute
DTSTART:20230614T140000Z
DTEND:20230614T153000Z
UID:TALK202108@talks.cam.ac.uk
CONTACT:114856
DESCRIPTION:Transcription factors\, histone methyltransferases\, DNA methy
 ltransferases\, CTCF\, and RNA pol II – which must necessarily bind chro
 matin - also bind RNA. In many cases\, the RNA and DNA binding sites overl
 ap enough that their binding is mutually antagonistic. We have determined 
 the cryo-EM structure of Polycomb Repressive Complex 2 (PRC2) bound to RNA
 \, which gives unexpected insights regarding the mechanism of RNA inhibiti
 on. Furthermore\, we find that PRC2 and other DNA- and RNA-binding protein
 s can be directly transferred or “handed off” between nucleic acid lig
 ands without a free protein intermediate. Such direct transfer may be nece
 ssary for these proteins to find their cognate binding sites in cells and 
 may be a prerequisite for biological condensates to facilitate recruitment
  of proteins to chromatin.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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