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SUMMARY:Using synthetic biology to understand pattern-forming gene regulat
 ory networks and their evolution - Professor Yolanda Schaerli from Departm
 ent of Fundamental Microbiology\, University of Lausanne  
DTSTART:20231019T130000Z
DTEND:20231019T140000Z
UID:TALK202174@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Studying gene regulatory networks in situ is very challenging\
 , due to their embedding in large and complex cellular networks. Synthetic
  biology offers a path forward. Synthetically recapitulating biological pr
 ocesses and interactions provides a bottom-up approach towards understandi
 ng the general principles of their mechanisms and evolution. By extracting
  a gene regulatory network from its native cellular environment\, it becom
 es feasible to systematically study the effects of mutations on the phenot
 ype of a gene regulatory network.\nIn my talk I will first show how we eng
 ineered synthetic gene regulatory networks in Escherichia coli to produce 
 spatiotemporal patterns such as oscillations and stripes [1\,2]. I will th
 en present how we used these synthetic circuits to study how the mechanism
 s of gene regulatory networks constrain evolution [3]\, to perform a syste
 matic analysis of epistasis [4] and to exemplify how the robustness of gen
 e regulatory networks might be driving the evolutionary innovation [5]. \n
 \n1)	A unified design space of synthetic stripe-forming networks\, (2014) 
 Nat. Commun.\, 5:4905 \n\n2)	Multistable and dynamic CRISPRi-based synthet
 ic circuits\, (2020) Nat. Commun.\, 11:2746 \n\n3)	Synthetic circuits reve
 al how mechanisms of gene regulatory networks constrain evolution\, (2018)
  Molecular Systems Biology\, 14:e8102 \n\n4)	Environment-dependent epistas
 is increases phenotypic diversity in gene regulatory networks\, (2023) Sci
 . Adv.\, 9:eadf1773 \n\n5)	Robustness and innovation in synthetic genotype
  networks\, (2023) Nat. Commun.\, 14:2454 \n\n\n
LOCATION:Biffen Lecture theatre and Zoom
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