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SUMMARY:Multiscale approaches for hierarchical biological materials - Gius
 eppe Puglisi (Politecnico di Bari)
DTSTART:20230803T101500Z
DTEND:20230803T111500Z
UID:TALK202456@talks.cam.ac.uk
DESCRIPTION:\n\n\n&nbsp\;\n\n\n\n\n\n\n\nWe present new approaches for a d
 irect deduction of the macroscopic properties of biological and rubberlike
  materials\, starting from a detailed discussion of the behavior at the mo
 lecular and cellular scale. By adapting classical methods of equilibrium a
 nd non equilibrium statistical mechanics\, we describe different types of 
 instabilities observed in polypeptide chains. From one side conformational
  transitions corresponding to the unfolding of crystal hard domains\, such
  as beta-sheets and alpha helices secondary structures are modeled by cons
 idering multiwells energy functions. From the other side bonds breaking as
  in the case of RNA/DNA denaturation or molecules and cell decohesion are 
 modeled by considering a &lsquo\;degenerate&rsquo\; second energy well\, c
 orresponding to constant (debonding) energy and zero force. In this way th
 e purely mechanical approaches for phase transition and hysteresis that we
  previously proposed&nbsp\; in discrete models based on the introduction o
 f internal (spin type) variables\, are extended to the cases when thermal\
 , rate\, and entropic effects cannot be neglected. Different phenomena wil
 l be described such as protein unfolding taking care of intermolecular or 
 external devices interaction\, non-local interactions and interfaces energ
 y effects\, intermediate &lsquo\;damaged&rsquo\; configurations anticipati
 ng decohesion. Based then on classical multiscale modelling and continuum 
 mechanics we deduce effective macroscale constitutive models with damage\,
  residual strains\, hysteresis\, healing\, growth and rate effects.\n\n\n\
 n\n\n
LOCATION:Seminar Room 1\, Newton Institute
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