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SUMMARY:The role of the extracellular matrix as a memory hub to coordinate
  collective cell behaviour during vascular growth - Daria Stepanova (Centr
 e de Recerca Matematica (CRM))
DTSTART:20231108T103000Z
DTEND:20231108T110000Z
UID:TALK203251@talks.cam.ac.uk
DESCRIPTION:I will discuss angiogenesis\, the process where new blood vess
 els sprout from existing vasculature\, crucial in development\, wound heal
 ing\, and the progression of numerous pathologies like cancer. While curre
 nt mathematical models often adopt a leader-follower framework to study ce
 ll behaviour during angiogenesis\, a closer look at endothelial cell dynam
 ics reveals a more complex pattern: cells actively exchange positions with
 in sprouts\, challenging the conventional modelling approaches. We investi
 gate how vascular sprouts maintain structural integrity amidst this dynami
 c cell behaviour. Our research emphasises the vital role of the extracellu
 lar matrix (ECM) in coordinating sprout growth. Through an agent-based mod
 el of early vascular growth\, we integrate cell rearrangements and their i
 nteraction with the surrounding matrix. Our model accurately replicates va
 scular integrity by incorporating ECM remodelling during cell migration. N
 otably\, this remodelled ECM serves as a memory hub\, effectively coordina
 ting blood vessel growth. Moreover\, since the intensity of cell-ECM inter
 action depends on subcellular signalling\, we also demonstrate that indivi
 dual behaviour of endothelial cells from different cell lines (with impair
 ed signalling) can be transmitted through ECM remodelling to obtain differ
 ent morphologies in the resulting vasculature. This perspective offers new
  insights into angiogenesis and analogous biological systems\, stressing E
 CM's essential role in guiding cellular movement.\nThis is a joint work wi
 th Tom&aacute\;s Alarc&oacute\;n\, Helen M. Byrne and Philip K. Maini.&nbs
 p\;
LOCATION:Seminar Room 1\, Newton Institute
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