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SUMMARY:Dynamics of growth\, collision\, and cell division in epithelial m
 onolayers - Carles Falco (University of Oxford)
DTSTART:20230911T123000Z
DTEND:20230911T131500Z
UID:TALK203341@talks.cam.ac.uk
DESCRIPTION:Although tissues are typically studied in isolation\, such sit
 uations rarely occur in biology\, as cells\, tissues\, and organs coexist 
 and interact across various scales\, shaping both form and function. In th
 is study\, we adopt a quantitative approach that combines recent experimen
 tal data\, mathematical modelling\, and Bayesian parameter inference to de
 scribe the dynamics of freely expanding and colliding epithelial monolayer
 s. Two simple and extensively studied continuum models are employed\, wher
 e cells move either randomly or in response to population pressure gradien
 ts. Following appropriate calibration\, both models successfully replicate
  the primary features of individual tissue expansions. However\, our findi
 ngs demonstrate that when tissues are not isolated and interactions become
  relevant\, assuming random cell motion can lead to unrealistic behaviour.
  In such cases\, a model that considers population pressure from different
  cell populations proves more suitable and facilitates comparison with exp
 erimental measurements. Additionally\, we investigate the dynamics of cell
  division within epithelial monolayers and demonstrate how a combination o
 f minimal modelling and Bayesian inference can capture mechanical checkpoi
 nts in cell-cycle progression.
LOCATION:Seminar Room 1\, Newton Institute
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