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SUMMARY:Spatial Patterning of Mitochondrial Energy Production in Mouse Ooc
 ytes - Yash Rana (Harvard University)
DTSTART:20230904T105000Z
DTEND:20230904T111000Z
UID:TALK203797@talks.cam.ac.uk
DESCRIPTION:Metabolism provides a continuous flux of energy that keeps liv
 ing systems out of equilibrium and gives rise to biological form and funct
 ion. Energy production is patterned across space and time within cells via
  the organization of mitochondria and spatial distributions in mitochondri
 al activity. Interestingly\, mitochondrial energy flux directly shapes the
  actin cytoskeleton\, which in turn drives intracellular motility and dete
 rmines the spatial organization of mitochondria. The physical mechanisms t
 hat give rise to these coupled emergent dynamics and their implication on 
 embryo development are unknown. In this talk\, I will share ongoing work w
 here I seek to decipher the mechanism behind the formation of subcellular 
 spatial patterns of mitochondrial metabolism in mouse oocytes. I do so thr
 ough the paradigm used to study complex systems in Physics by integrating 
 quantitative microscopy\, mechanical perturbations\, and coarse-grained bi
 ophysical theory. Understanding these mechanisms in mouse oocytes will tea
 ch us quantitative cell biological principles that underlie the patterning
  of energy fluxes within cells. It will also provide insight into the crit
 ical role of sub-cellular energy fluxes in mammalian development and the n
 on-equilibrium thermodynamics of living active matter.
LOCATION:Seminar Room 1\, Newton Institute
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