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SUMMARY:Strong deformation of 3D cellular aggregates: from cellular deform
 ation to elastocapillarity - Helene Delanoë-Ayari (Université Claude Ber
 nard Lyon 1)
DTSTART:20230905T084000Z
DTEND:20230905T092000Z
UID:TALK203821@talks.cam.ac.uk
DESCRIPTION:Mechanical constraints significantly influence physiological a
 nd pathological processes. Three dimensional cell aggregates are now exten
 sively used as models for tissue engineering\, development\, or cancerous 
 tumours. We will present experiments involving the aspiration of such aggr
 egates through narrow microfluidic channels. This generates heteregeneous 
 flows and substantial cellular deformations\, which can be visualized at c
 ellular scale using two-photon microscopy. This innovative approach enable
 s the measurement of local viscoelastic properties of 3D tissues. We corre
 late these properties with intracellular and intercellular ingredients suc
 h as changes in cell shape\, cell rearrangements\, and protein expression 
 levels. Finally\, these experiments are a useful benchmark to investigate 
 elasto-capillar effects balancing cell deformation with aggregate surface 
 tension.
LOCATION:Seminar Room 1\, Newton Institute
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