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SUMMARY:The geometric basis of epithelial convergent extension - Fridtjof 
 Brauns (University of California\, Santa Barbara)
DTSTART:20230906T103000Z
DTEND:20230906T105000Z
UID:TALK203848@talks.cam.ac.uk
DESCRIPTION:Shape changes of epithelia during animal development\, such as
  convergent extension\, are achieved through concerted mechanical activity
  of individual cells.&nbsp\;While much is known about the corresponding la
 rge scale tissue flow and its genetic drivers\, the question of cell-scale
  coordination remains open. We propose that this coordination can be under
 stood in terms of mechanical interactions and instantaneous force balance 
 within the tissue.&nbsp\;Using whole embryo imaging data for Drosophila ga
 strulation\, we exploit the relation between balance of local cortical ten
 sion forces and cell geometry. This unveils how local positive feedback on
  active tension and passive global deformations account for coordinated ce
 ll rearrangements.&nbsp\;We develop a model that bridges the cell and tiss
 ue scale dynamics and predicts the dependence of total tissue extension on
  initial anisotropy and hexagonal order of the cell packing.&nbsp\;Our stu
 dy provides general insight into the encoding of global tissue shape in lo
 cal cell-scale activity.\nCo-Authors: Nikolas Claussen\, Boris Shraiman
LOCATION:Seminar Room 1\, Newton Institute
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