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SUMMARY:The Drosophila Tracheal Terminal Cell: an intriguing model system 
 for growth and distribution - Tatyana Gavrilchenko (Simons Foundation)
DTSTART:20230907T105000Z
DTEND:20230907T111000Z
UID:TALK203875@talks.cam.ac.uk
DESCRIPTION:The insect respiratory system is a network of air-filled tubes
  permeating the animal body\, supplying oxygen for metabolic activity and 
 removing waste carbon dioxide. The majority of gas exchange occurs in the 
 finest regions of the tracheal system\, the terminal cells. These cells ha
 ve a unique and highly specialized tree-like structure with long thin bran
 ches\, reminiscent of neuronal arbors. While many aspects of the terminal 
 cell are understood on a molecular level\, including the mechanisms that g
 uide branch extension and lumen formation\, the macroscopic network featur
 es that allow for proper oxygen distribution remain mysterious. We use the
  terminal cell as a model system for several developmental problems\, util
 izing an imaging data set that fully maps the structure of hundreds of ind
 ividual cells. The benefits of our investigations are insights into proper
 ties of mammalian capillary networks\, which have different structural fea
 tures and delivery mechanisms from terminal cells but are believed to be g
 uided by similar developmental principles. Understanding the salient featu
 res that govern the structure of these biological networks is essential to
  designing synthetic vasculature\, a major step in the manufacture of arti
 ficial organs.
LOCATION:Seminar Room 1\, Newton Institute
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