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SUMMARY:Collective Dynamics of Neural Progenitor Cells: A New Mechanism of
  Accumulation at Integer Topological Defects - Masaki Sano (Shanghai Jiao 
 Tong University)
DTSTART:20230907T125000Z
DTEND:20230907T133000Z
UID:TALK203881@talks.cam.ac.uk
DESCRIPTION:Co-Authors: Zihui Zhao\, He Li\, Yison Yao\, Yonfeng Zhao\, Fr
 ancesca Serra\,\nRecently\, collective motions and morphogenesis of cell m
 onolayers around topological defects have attracted much attention in stat
 istical physics\, soft matter\, and biophysics. However\, validity and uni
 versality of the governing equations for those systems are still in debate
 . Neural Progenitor Cells (NPCs) have an elongated shape and reciprocate a
 long their elongated axes\, forming nematic orientational order. We induce
 d integer topological defects with different director angles by using micr
 ofabrication on the substrate. Integer topological defects are usually dif
 ficult to appear spontaneously except in rosette structures composed of po
 larized cells. We found that all types of +1 topological defects\, includi
 ng aster (radial)\, spiral\, and circular patterns\, attract cells toward 
 the centers of the defects. &nbsp\;This phenomenon cannot be explained by 
 the well-known models of dry active nematics. The analysis of the flow and
  orientation fields consistently show deviations from the minimum model. H
 owever\, we have successfully reproduced this phenomenon by constructing a
  model of nematically interacting active particles. We also found that the
  new equations obtained from the hydrodynamic representation of the partic
 le model correctly reproduce this phenomenon. These results provide a new 
 perspective on the characterization of cell monolayer dynamics.\n&nbsp\;
LOCATION:Seminar Room 1\, Newton Institute
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