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SUMMARY:Using model active tissues containing active chromatin to test mul
 ti-scale hypotheses in cellular collectives - Jennifer Schwarz (Syracuse U
 niversity)
DTSTART:20230906T105000Z
DTEND:20230906T112000Z
UID:TALK203899@talks.cam.ac.uk
DESCRIPTION:Organoids are&nbsp\;in vitro cellular collectives that give us
  a window into morphogenesis.&nbsp\; In such collectives\, the DNA scale i
 s key to determining organoid structure\, be it brain\, kidney\, or heart.
  Using a three-dimensional vertex model as a cellular-based model for an o
 rganoid with embedded model cell nuclei\, we begin to address this hierarc
 hy-of-scales phenomenon by focusing on the simpler chromatin-to-tissue sca
 le organization puzzle. We show that such a minimal\, multi-scale model ca
 n be used test a hypothesis regarding a mechanism by which the size of hum
 an-derived brain organoids differs from the size of chimpanzee-derived bra
 in organoids\, for example.&nbsp\;&nbsp\;
LOCATION:Seminar Room 1\, Newton Institute
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