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SUMMARY:Simple Chromosome Partitioning Mechanisms Driven by Molecular Moto
 rs - Francois Nedelec (University of Cambridge)
DTSTART:20230908T134000Z
DTEND:20230908T142000Z
UID:TALK203902@talks.cam.ac.uk
DESCRIPTION:We are using theory to explore simple mechanisms of chromosome
  partitioning with the aim of understanding the design principles of mitot
 ic spindle assembly. Firstly\, I will present how artificial evolution in 
 a computer can uncover simple combinations of cytoskeletal elements that w
 ill self-organize to pull on a kinetochore pair symmetrically and reliably
 . Secondly\, I will discuss the requirements to extend such elementary mec
 hanisms to build a mitotic spindle that can handle multiple chromosomes. F
 inally\, I will present the characteristics of the mitotic spindles found 
 in the roots of Arabidopsis thaliana\, and argue that given these quantiti
 es\, this plant spindle stands out as an ideal subject to build a quantita
 tively accurate 3D simulation. I will present our attempts to build such a
  model\, detailing the key assumptions and discussing the different aspect
 s that appear correct or still need to be worked out.&nbsp\;
LOCATION:Seminar Room 1\, Newton Institute
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