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SUMMARY:Solid and Fluid Mechanics for Cardiovascular Engineering - Ajay B 
 Harish (University of Manchester)
DTSTART:20230822T130000Z
DTEND:20230822T140000Z
UID:TALK204241@talks.cam.ac.uk
DESCRIPTION:AAA is a serious condition in which the size of the abdominal 
 aorta starts to increase and can eventually lead to rupture. In the last d
 ecade\, the UK has witnessed an average of 3000 AAA-related deaths annuall
 y\, equating to approximately one death every three hours. Globally\, the 
 average was estimated to exceed 150\,000 deaths per year over the last dec
 ade\, which translates to about one death every three minutes. Understandi
 ng the growth of an aortic aneurysm and developing personalised assessment
 s has been classified as one of the top three priorities by the Vascular S
 ociety of Great Britain and Ireland. In our work\, we explore the use of h
 igh-fidelity Computational Fluid Dynamics (CFD) to predict wall shear stre
 ss (WSS). However\, WSS can only be derived for timescales of 1-2 cardiac 
 cycles\, whereas appreciable growth occurs over months. We employ solid me
 chanics growth models in conjunction with uncertainty quantification (UQ) 
 to couple these timescales and predict probabilistic growth scenarios for 
 abdominal aortic aneurysms. Additionally\, we delve into the potential app
 lications of machine learning for predicting WSS and growth based on the g
 eometry.
LOCATION:Seminar Room 2\, Newton Institute
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