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SUMMARY:Fate determination of retinal neurons: Lineage relationships and t
 he inhibitory master switch Ptf1a - Dr. Patricia Jusuf
DTSTART:20091125T130000Z
DTEND:20091125T140000Z
UID:TALK20464@talks.cam.ac.uk
CONTACT:John Mollon
DESCRIPTION:During neurogenesis of the central nervous system (CNS)\, a mu
 ltitude of different neuronal types form from undifferentiated progenitor 
 cells. We study the mechanisms of cell fate determination of visual neuron
 s in the zebrafish retina\, an accessible and highly organised part of the
  CNS. \n\nThe different retinal neuron types are born at different develop
 mental times from multipotent progenitors. In the current model of neuroge
 nesis\, progenitor cells undergo temporal changes in competence states (dr
 iven by changes in the complement of genes expressed at any given time) th
 at bias differentiating neurons towards particular fates. \n\nHere\, I wil
 l introduce some of key genes that drive fate determination and how the li
 neage of cells expressing these different genes relate to each other. My c
 urrent work focuses on the role of the pancreas transcription factor 1a (P
 tf1a)\, which has been implicated in determination of inhibitory cell fate
 s throughout different CNS regions including the retina. \n
LOCATION:Kenneth Craik Room\, Craik-Marshall Building\, Downing Site
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